Distress is related to cancer diagnosis and treatment and is explicitly tied to a number of common practical, physical, and psychologic problems. Throughout cancer treatment different levels of distress can be expected and related to changes phases. Therefore, we sought to characterize the distribution of distress level over three points of evaluation, considering the duration of chemotherapy protocol (average range of two and a half months between each assessment). To compose the sample, a total of 261 patients of a Brazilian cancer center, completed all the phases of evaluation, through the Distress Thermometer. They had a mean age of 53.3 years (SD = 15.5), 67% were women and 33% were men, most of them were married (63.2%), and 58.6% had at least college degree. The main forms of cancer were breast (27.6%), hematological (24.1%) and gastrointestinal (23.7%). In the beginning of the treatment (T1) 55.2% of patients were with significant distress (DT ≥ 4). At the middle (T2) 21.8% of patients remained with high distress, 33.4% reduced distress level, 43.3% remained with low distress, and 1,5% increased distress level. At the last day of chemotherapy (T3) 8% remained with high distress, 15.3% reduced distress level, 71.3% remained with low distress, and 5.4% increased distress level. The demographic characteristic and the problems related distress, considering the distress level behavior over the points of evaluation will be presented at the meeting. Moreover, the present findings shows a high incidence of distress, with a progressive decrease in reevaluation stages, not for all patients, which increased or persisted with high level of distress. We can observed that low distress in T1 is a good indicator for patients maintain low distress throughout the treatment.