Suffering is a common phenomenon experienced by patients with cancer, particularly advanced cancer. This qualitative study aims to describe the experiences of patients with terminal advanced cancer. Series interviews and participant observation were conducted on 15 patients with terminal advanced cancer.  Thematic analysis was applied. The findings reveal that living with suffering was the dominant theme. The causes of suffering include physical symptom distress, feeling of alienation, sense of worthlessness, sense of burden to others and desire for hastened death. The study also highlights the importance of psycho-spiritual interventions to alleviate suffering among the dying patients with advanced cancer.